Structural and functional modules in RNA interference
نویسندگان
چکیده
منابع مشابه
RNA interference in functional genomics and medicine.
RNA interference (RNAi) is the sequence-specific gene silencing induced by double-stranded RNA (dsRNA). Being a highly specific and efficient knockdown technique, RNAi not only provides a powerful tool for functional genomics but also holds a promise for gene therapy. The key player in RNAi is small RNA (approximately 22-nt) termed siRNA. Small RNAs are involved not only in RNAi but also in bas...
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15 صفحه اولStructural and functional insights into human Tudor-SN, a key component linking RNA interference and editing
Human Tudor-SN is involved in the degradation of hyper-edited inosine-containing microRNA precursors, thus linking the pathways of RNA interference and editing. Tudor-SN contains four tandem repeats of staphylococcal nuclease-like domains (SN1-SN4) followed by a tudor and C-terminal SN domain (SN5). Here, we showed that Tudor-SN requires tandem repeats of SN domains for its RNA binding and clea...
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ژورنال
عنوان ژورنال: Current Opinion in Structural Biology
سال: 2009
ISSN: 0959-440X
DOI: 10.1016/j.sbi.2009.04.006